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Process response to injury hypothesis response

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Unformatted text preview: ame Characteristics Definition – – – Artery occluded by plaque and connective tissue, no fresh thrombus www.siumed.edu/~dking2/crr/images/CR026b.jpg Sequence in the Evolution of Atherosclerotic Lesions Atherosclerotic Stary 2000 How does the atherosclerotic process begin? process Response to Injury Hypothesis Response Under normal conditions the endothelium protects against atherosclerosis. Porth 2007 Mechanical Factors Leading to Atherosclerosis Atherosclerosis – Chaotic and unorganized – Forward and backward movements Zarins 1983 Risk Factors Leading to Atherosclerosis Atherosclerosis Modifiable – – – – – – – – Hypertension Type A personality Cigarette smoking Diabetes Nonmodifiable – – – Nonlinear Relationship Between Risk Factors and CHD Risk McArdle, Katch and Katch Coronary Artery Disease Coronary Majority of atherosclerosis in – – – Proximal portion of Proximal portion of Entire length of Dalager 2007 Myocardial Infarction Myocardial Myocardial Infarction is commonly known as a . Ischemic death of myocardial tissue as a result of insufficient blood flow. Majority of MI’s are a result of a Irreversible myocardial cell death begins after minutes of ischemia. Porth 2007...
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