PRINCIPLES OF EXPOSURE (TOXICOLOGY OVERVIEW)

PRINCIPLES OF EXPOSURE (TOXICOLOGY OVERVIEW) - PRINCIPLES...

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PRINCIPLES OF EXPOSURE S. R. DiNardi, Ph.D., CIH University of Massachusetts, Amherst Professor and Chair Emeritus School of Public Health and Health Sciences Adjunct Professor of Public Health at USC
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THIS IS ©COPYRIGHTED MATERIAL NEITHER THESE SLIDES NOR THESE NOTES OR ANY PART THEREOF MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPYING, EMAIL, SCANNING, MICROFILMING, FACSIMILE AND RECORDING, OR BY ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE AUTHOR: SALVATORE R. DINARDI, Ph.D., CIH SHUTESBURY, MASSACHUSETTS sdinardi@schoolph.umass.edu and COLUMBIA, SOUTH CAROLINA sdinardi@sc.rr.com This material is intended for use in NURSING 504 during the Fall 2010 semester at the University of South Carolina, Columbia, SC AUGUST 2010
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COPYRIGHTED BY S. R. DINARDI 3 OUTCOME COMPETENCIES Upon completion of this class, the student will be able to: ± Describe toxic materials ± Describe the concept of dose/response ± Define exposure and modes of action ± Define acute and chronic effects of exposure ± Define local and systemic effects of exposures
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COPYRIGHTED BY S. R. DINARDI 4 THE WORLD OF CHEMICALS ± UNIVERSE OF CHEMICALS > 5 MILLION ± INDUSTRIAL INVENTORIES ~ 55,000 ± REGULATED OCCUPATIONALLY ~ 800
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COPYRIGHTED BY S. R. DINARDI 5 POISONS "ALL SUBSTANCES ARE POISONS; THERE IS NONE WHICH IS NOT A POISON. THE RIGHT DOSE DIFFERENTIATES A POISON AND A REMEDY." PARACELSUS (1493-1541)
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COPYRIGHTED BY S. R. DINARDI 6 Philippus Aureolus Theophrastus Bombastus von Hohenheim: "Paracelsus"(1490-1541) Contemporary print of Paracelsus. Part quack, part physician of genius, Paracelsus claimed "...I possess a secret
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PRINCIPLES OF EXPOSURE (TOXICOLOGY OVERVIEW) - PRINCIPLES...

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