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SCAN0094 - 343 P63 Mr my Reglflation 0f GS...

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Unformatted text preview: 343 P63 Mr»! my?) Reglflation 0f GS ACtiVity (poskmmlcdxcMQ W) Two Mechanisms: 1) catalytic activity (turnover #) 4f“ -> Adenylationldeadenylation of GS “W AMPImw)—>C\5c‘aam RMPHW — 035 (N (Mfivtmca hm WU +5 ‘in,) 2) Allosteric Inhibition of GS activity: (21“) 1) Glutamine '“ 2) A!ar!'r!e 5 amino acids represent (N- excess) 3) HISt'dlne 5/6 major a.a. biosynthetic m aivsengeq) AM? 4) Tryptophan families 5) Glycine 6) glucosamine-G-P (Sky/W90 Nah £171 hat} -> GS activity is allosterically inhibited 1/6 by binding of each of 6 inhibitors at separate allosterlc sites on GS ...
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