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SCAN0008 - H-DNA conformation Discovered in 1980’s...

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Unformatted text preview: H-DNA conformation Discovered in 1980’s - Plasmid DNA in solution under sufficient torsional stress See if sequence has inverted repeat homopyrimidines on one strand spaced by 4-10 bases. vmoa PUSIME’NCH STRAND (Pu)nYNHK(Pu)n (Py)n?><YZD(Py)n Occurs in some plasmids in vitro with supercoiling. In vivo occurrence? Main Point: Several unusual tertiary structures exist. Can influence and be influenced by supercoiling (unwinding torsion). Specific function(s) unclear. ...
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