Unformatted text preview: H-DNA conformation
Discovered in 1980’s - Plasmid DNA in solution under sufﬁcient torsional stress See if sequence has inverted repeat homopyrimidines on one
strand spaced by 4-10 bases. vmoa PUSIME’NCH STRAND (Pu)nYNHK(Pu)n
(Py)n?><YZD(Py)n Occurs in some plasmids in
vitro with supercoiling. In vivo occurrence? Main Point: Several unusual tertiary structures exist. Can inﬂuence and be inﬂuenced by supercoiling (unwinding
torsion). Speciﬁc function(s) unclear. ...
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- Fall '09