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SCAN0021 - Viollier et al 2004 PNAS Study Caulobacter...

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Unformatted text preview: Viollier et al 2004 PNAS- Study Caulobacter crescentus G1 phase cells — better synchrony for initiation Create 112 strains — lac & tet repressor binding sites at known positions in genome. plasmid induced fluorescent protein fused to repressors Results Positions of sitesmalgmnmg long axis of cell linearly __ WW dependefifon distance from orlgln! . “\m "MI/2 ........\_.'M~W Another Perspective— Role of coupled transcription- translation and insertion of some proteins into membrane Woldringh Molecular Microbiology (2002) 45, 17-29 1. Transcription and translation are physically coupled 2. When proteins are inserted to membrane they tether/pull DNA close to membrane sites 3. Creates a bias for chromosome segregation as membrane grows longitudinally. 4. May explain ~45 separate domains of nucleoid supercoiling. ...
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