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SCAN0044 - Regulating Transcription a For cell’s...

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Unformatted text preview: Regulating Transcription a) For cell’s constitutive needs; some genes need a lot, other genes little. b) enable response to environmental changes Regulating Transcription Initiation Promoter sequence has a major effect e.g.: constitutive rates rRNA gene promoter: 1 start/sec LacI gene promoter : 1 start/ 15 0 sec Studies on transcription initiation McClure 1985 - compared in vitro initiation rates & in vivo rates of various promoters. Find they are correlated. For a given promoter: in vivo - measure # transcripts/ cell cycle (has (MW W Mills} in vitro- promoter ‘strength’: rate of abortive initiation 20 We 1?; 15 In Vitl'O rate in vivo rate ...
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