Unformatted text preview: yd Active Sites on ribosomes @Decoding center - l6S rRNA base pairs to SD sequence on mRNA, also interacts with tRNA 0 Peptidyl transferase site — 23S rRNA bases are critical
A2451 - ~100% conserved
- mutagenesis- dominant lethal
- no protein within 18A radius H .~ U8 ‘ﬂbm
Implies ribosome initially a ribozyme, BUT in 2002-3 Reanalysis of structure at 2451 shows at different position. Can substitute ...
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- Fall '09