Unformatted text preview: Elongation requires participation of elongation
factors - EF-Tu (also called EF1A) binds aa-tRNA . EF-Ts (EF1B) interacts with EF—Tu;
GDP<—>GTP - EF-G (EF2) needed for mRNAtranslocation EF-Tu & EF-G are small GTP-binding proteins.
A summary of the sequence of events follows. Elongation cycle Ribosorne structure
and position of
factors & tRNAs
based on cryo-EM
with 3D image
reconstruction. (Dr. J. Frank). Colors: large ribosome subunit, cyan; smallvsubunit, pale
yellow; EF-Tu, red; EF-G, blue. tRNAs, gray, magenta, green, ...
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- Fall '09