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SCAN0032 - BRINGING tRNA TO A Site EF-Tu-GTP binds and...

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Unformatted text preview: /\., BRINGING tRNA TO A Site EF-Tu-GTP binds and delivers an aminoacyl-tRNA to the A site. aa-tRNA must have the correct anticodon to base pair with the mRNA codon positioned at the A site. tRNA binding causes a conformational change in the small ribosomal subunit. Conformational Change causes universally conserved bases of 16S rRNA to interact with the first two base pairs of the codon/anticodon complex in A site. ( 1995-2001- structures, NMR ) Proofreading- lf ribosome conformation is not stabilized by this interaction, aa-tRNA released prior to peptide bond formation. ...
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