Unformatted text preview: Stereochemical basis of genetic code?
M Yarus et al —Annual Rev. Biochem.2005 RNA coding triplets (codons and anticodons) arose initially from specific affinity of RNA base triplets for
their cognate amino acids: Test hypothesis: Test using SELEX. Generate random RNAs; select for those
that bind to 8 amino acids Amino acids tested: Phe, His, lle, Leu, Glu, Arg, Trp, Tyr, Find: Probability of randomly seeing codon
association as great as observed is 6.6x10'3 Probability of randomly seeing anticodon
association as great as observed is 1.1x10'10 11 ...
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- Fall '09