Unformatted text preview: Protein Folding After Their Synthesis Do proteins fold (after denaturation) into their functional
conformation in vitro ? 1970’s — Ribonuclease and some others, yes Many other proteins, no. What factors govern protein folding to functional state? Theoretical/Ex erimental Studies 1970’s to now Main driving force for folding — interaction of hydrophobic
patches Studies on Ribosome enerated roteins in vitro
- Some spontaneously‘fold to active form . Others do ﬂgt spontaneously fold/assemble
to active form. Form stable inactive conformation. ...
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- Fall '09