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SCAN0050 - Protein Folding After Their Synthesis Do...

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Unformatted text preview: Protein Folding After Their Synthesis Do proteins fold (after denaturation) into their functional conformation in vitro ? 1970’s — Ribonuclease and some others, yes Many other proteins, no. What factors govern protein folding to functional state? Theoretical/Ex erimental Studies 1970’s to now Main driving force for folding — interaction of hydrophobic patches Studies on Ribosome enerated roteins in vitro - Some spontaneously‘fold to active form . Others do flgt spontaneously fold/assemble to active form. Form stable inactive conformation. ...
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