CHFD 3710 - Free Radicals Theory The oxygen paradox Need it...

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CHFD 3710 What can damage DNA? oxidative lesions] Damage can lead to mutations when cell divides Large number of defective proteins leads to cell and tissue death Cross Linking Theory Glycation Caused by long-term exposure of proteins to glucose Causes proteins to bind together(cross-link) Increases with age Cross links toughen tissue Stiffened connective tissue Hardened arteries Macrophages fight glucose molecules but defense breaks down with age; cross links increase over time
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Unformatted text preview: Free Radicals Theory The oxygen paradox Need it to live Can damage cells Molecules with unpaired electron, free energy, bond with other molecules Can damage tissues, other molecules Caused by normal cell metabolism Musculoskeletal system Muscle and bone content decrease Can decrease 50% by age 80 Age 20+ Bones lose more cells than are replaced Lose hardness and density *osteo-bone* *porosis- porous; spongy* Sensory changes Taste Taste buds decline in number & decrease in size Less sensitivity to sweet & salty...
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CHFD 3710 - Free Radicals Theory The oxygen paradox Need it...

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