Unformatted text preview: _ 29. 30. ' ‘31. 32. Which of the following statements regarding nucleic acid structure is FALSE? A. A When complementary regions of DNA or RNA form double strands. a purine /' usually pairs with a pyrimidine.
GC’rich DNA is more resistant to heat denaturation than AT-n'ch DNA. V All nucleic acid bases are covalently attached to the 1' position of the ribose B.
@ Most-whryotic mRNA molecules have a special 'cnp' structure on (a? ‘4
‘1 ends. @UMW‘QOXC— N009— NQ\€Lu\Q,_\‘anQ QC 0“ 8 p1 All nucleotides in pmkaryotic mRNA are 1mm in s' - 3" linkages. W
Jrth Dihydrofolatereductase (DHFR) is required for synthesis of tetrahydrofolate ('I'EF); wigth’
tetrahydrofolate is required for synthesis of 5. ill-methylene THF and N‘°—formyl _ . £1 _, 5
THE. Methotrexate is an inhibitor ofdihydrofolatevreduetase (Darn). In 0 r “a 'J
mammalian cells treated with methotrexate, 512.0919 synthesis of which compound
below. Mil NOT be Inhibited? » pl C -- (“Q #7Qw‘?\\Q_dLua> Q
A. ~ nGuanosin‘e tn'phosphate
B. Deoxythymidine mmophosphate
C. Inosine monophosphate % .
go? Cytidine uiphosphate X
E. — Adenosinemonophosphate 95C“?-
DNA sequencesfromhuman gene X are inserted into aqbacterial plasmid and .
transfeeted into g. c011. Which of the following is NOT required for production of
functional protein X, and enzyme, in bacteria?
A. 'Driving' gene X with a cloned bacterial promoter.
® SubsnateforproteinXinthebacteria. . p
C.‘ Removing lntmn sequences from gene X before insertion of gene X sequences
into the plasmid. _ ' ~
D. .A Shine—Dalgarno "sequence.
a A Pribnow (TATAAT) box. . «ﬂow 191‘“ . , «0‘5
Which of the following statements is rm ’ _ ‘ .o‘iW’ MW
43:. RNA and DNA synthesis both usually require endonuelease activity.
B. DNA replication in mammals is bidirectional. / ‘ ‘
C. RNA synthesis from a given mammalian gene is unidirectional. \/
D. DNA replication occurs on both strands of DNA simultaneously.
E. Transcription of a given mammalian gene usually occurs from one strand only. V M mplmwwd N39. ahDaés situate WM 6mm 90 QWoi’cls
MW. 5W I55 ...
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- Spring '08