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Lecture 9-development and hormones

To stagesofcellularactivity 1 neurogenesis mitotic

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Unformatted text preview: hat are the cellular processes that contribute to the morphological development of the brain? to Stages of Cellular Activity • 1. Neurogenesis mitotic division of non-neuronal cells to produce neurons • • • • • (occurs in neural tube) 2. Cell migration movement of cells to establish distinct populations 3. Differentiation transformation of neuron into distinct types 4. Synaptogenesis establishment of synaptic connections as axons and dendrites grow 5. Cell death 6. Synaptic remodeling loss/growth of synapses to refine connectivity 1. Neurogenesis­ birth of new neurons Cells • Cells on the inner surface of the neural tube divide (mitosis) and form a densely packed ventricular zone These cells aren’t neurons These yet, they are ‘progeny cells’ yet, This ‘ventricular mitosis’ is This the source of all neurons and glia and Ventricular mitosis occurs Ventricular primarily before birth (few cells born after birth) cells • • • 1. Neurogenesis­ birth of new neurons Shown • Shown here is a small section of the well of the neural tube at an early stage of embryonic development development At this early stage there is a At ventricular zone (the location of cell birth, i.e. ventricular mitosis) ventricular Progeny cells (still not Progeny differentiated cells yet) migrate from ventricular layer to the marginal layer (labeled ‘M’ on right) • • 1. Neurogenesis­ birth of new neurons Later • Later in embryonic development the wall of the neural tube thickens and an intermediate layer form (labeled ‘I’ on diagram to the right the Again, all neuron and glia Again, are derived from these progeny cells,...
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