3. communication hormones 2010

3. communication hormones 2010 - Hormones may be: 1....

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3. Communication - hormones 1 Hormones may be: 1. Peptides -NLS - growth hormone, insulin, atrial naturitic peptide - stored in secretory vesicles prior to release - requires plasma membrane receptor on target tissue 2. Metabolites of amino acids (amines) - mostly NLS - Epi and NE, dopamine, serotinin, thyroid hormone (LS) - NLS stored in secretory vesicles prior to release - NLS - require plasma membrane receptor on target tissue LS - cytosolic or nuclear receptor on target tissue 3. metabolites of cholesterol - steriod hormones -LS - cortisol, aldosterone, androgens (estrogen, progesterone, testosterone) - produced and released when needed - cytosolic or nuclear receptors
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3. Communication - hormones 2 General characteristics: 1. 1/2 life in blood 2. carrier proteins a) hormones circulate bound to a carrier or free - only free hormone is available to interact with target b) provides reservoir c) extends 1/2 life 3. Target tissue receptors required - # of receptors not constant - constant turnover -downregulated or upregulated 4. Permissive - hormone A must be present to get full effect of hormone B.
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3. Communication - hormones 3 hormone 1 in blood hormone 2 in blood hormone 3 in blood target cells change cell function Endocrine gland hormone 3 secretion - Control of secretion: 1. Feedback - negative - positive hormone 2 secretion Anterior pituitary hormone 1 secretion Hypothalamus - - -
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3. Communication - hormones 4 2. cyclic secretion - oscillating, pulsatile cycles following circadian rhythms - daily, sleep/wake, light/dark, seasonal (temp., tides, variations on length of day light), developmental cycles (puberty). suprachiasmatic nucleus (hypothalamus) circadian clock coordinated rhythms endocrine secretion metabolic processes behavioral activity Intrinsic 24-25 hour cycle light eyes LGN sleep-wake cycle
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3. Communication - hormones 5 B&Lpg883,893 3. neuronal - increase or decrease secretion in response to internal or external stimuli.
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3. Communication - hormones 6 Ca ++ regulation bone Interstitial space Extracellular fluid [Ca ++ ]plasma gut kidney
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3. Communication -
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3. communication hormones 2010 - Hormones may be: 1....

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