4 GIT 2010 - upper esophageal sphincter lower esophageal sphincter pyloric sphincter gall bladder sphincter of Oddi ileocecal sphincter anal

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4. Gastrointestinal tract 1 From Boron and Boulpaep pg 934 upper esophageal sphincter pyloric sphincter lower esophageal sphincter gall bladder sphincter of Oddi ileocecal sphincter anal sphincters
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4. Gastrointestinal tract 2 From Bern and Levy pg 590
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4. Gastrointestinal tract 3 From Silvethorn pg 607
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4. Gastrointestinal tract 4 secretory cells chemo Rc mechano Rc osmo Rc Enteric nervous system connectivity From Guyton pg 721
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4. Gastrointestinal tract 5 Stanfiels pg 596 -40 -10
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4. Gastrointestinal tract 6 SECRETIONS: 1. salivary glands 2. stomach 3. pancreas 4. liver 5. small intestine 1. Salivary Glands - parotid, submandibular (submaxillary) and sublingual secrete: a) saliva b) serous cells (parotid) - α -amylase -lipase c) mucous cells (submaxillary and sublingual) - mucin Control of secretion: lumen ISS 3Na+ 2K+ ATP Na+ IP 3 cAMP Ca++ SNS PNS + + Na+ H 2 O amylase lipase
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4. Gastrointestinal tract 7 2. Gastric secretions (stomach) a) Columnar epithelial cells and mucous cells - mucous -HCO 3 - b) Pareital cells - HCl - intrinsic factor c) Cheif cells - pepsinogen d) G cells - gastrin e) D cells - somatostatin f) enterochromaffin-like cells - histamine
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4. Gastrointestinal tract 8 Parietal cell K+ H+ ATP Cl- HCO 3 - Cl- 3Na+ 2K+ ATP CO 2 + H 2 O H 2 CO 3 HCO 3 - + H + CA K+ intrinsic factor metabolism muscarinic cholinergic Rc histamine Rc gastrin/CCK B Rc somatostatin Rc prostaglandin Rc Ca++ Gastrin Intrinsic factor cAMP histamine ACh hyperpolarize K+ channels on basolateral side Cl- channels H+-K+ ATPase on apical side driving force out for Cl- somatostatin prostaglandins Control of acid secretion lumen ISS K+ + - + + -
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4. Gastrointestinal tract 9 Cheif cells 3Na+ 2K+ ATP pepsinogen muscarinic cholinergic Rc beta adrenergic Rc gastrin/CCK A Rc secretin Rc
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This note was uploaded on 12/13/2010 for the course HK 3940 taught by Professor Murrant during the Fall '10 term at University of Guelph.

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4 GIT 2010 - upper esophageal sphincter lower esophageal sphincter pyloric sphincter gall bladder sphincter of Oddi ileocecal sphincter anal

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