5. Blood flow Heart and vasc

5 Blood flow Heart - Negative feedback regulation OVERRIDE COORDINATING CENTRE SENSOR EFFECTOR negative feedback 5 Regulation of blood flow Heart

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5. Regulation of blood flow - Heart and Vasculature 1 Negative feedback regulation negative feedback OVERRIDE SENSOR EFFECTOR COORDINATING CENTRE
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5. Regulation of blood flow - Heart and Vasculature 2 Pump Pump transport resistance exchange storage storage transport exchange resistance 64% 7% 7% 13% 9%
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5. Regulation of blood flow - Heart and Vasculature 3 Silverthorn pg 413
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5. Regulation of blood flow - Heart and Vasculature 4 Conduction Tissue Velocity (m/s) SA node 0.05 Artial pathways 1.0 AV node 0.05 Bundle of HIS 1.0 Purkinje system 4.0 Ventricular muscle 1.0
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5. Regulation of blood flow - Heart and Vasculature 5 Vm (mV)
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5. Regulation of blood flow - Heart and Vasculature 6 Silverthorn page 486
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5. Regulation of blood flow - Heart and Vasculature 7 Vm (mV)
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5. Regulation of blood flow - Heart and Vasculature 8 Berne and Levy p. 302
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Heart and Vasculature 9 Silverthorn p.494
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5. Regulation of blood flow - Heart and Vasculature 10
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5. Regulation of blood flow - Heart and Vasculature 11 Aortic EDV ESV
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5. Regulation of blood flow - Heart and Vasculature 12 Mitral valve opens Mitral valve closes Atrial contraction Berne and Levy p. 326.
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5. Regulation of blood flow - Heart and Vasculature 13 2. ESV i) intrinsic regulation 80 130 Silverthorn p. 501 Berne and Levy p. 264
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5. Regulation of blood flow - Heart and Vasculature 14 ii) nervous innervation (extrinsic) - direct innervation to cardiac myocytes. SNS NE cardiac myocytes β -adrenergic Rm protein kinases phosphorylation of: Gs AC cAMP 1. volt. dep. Ca ++ channels (L-type) # channels that open per AP trigger Ca ++ …… contractility 2. Ca ++ pumps on SR activity relaxation time speed of contraction
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5. Regulation of blood flow - Heart and Vasculature 15 iii) hormonal control SNS EPI/NE adrenal glands cardiac myocytes PNS ACh cardiac myocytes muscarinic cholinergic Rm protein kinases phosphorylation of: Gi AC cAMP 1. volt. dep. Ca ++ channels (L-type) 2. Ca ++ pumps on SR β -adrenergic Rm iv) paracrine – endothelial cells line the heart v) afterload
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5. Regulation of blood flow - Heart and Vasculature 16 3. HR i) neural control PNS ACh SA node (AV node) K + permeability hyperpol. spontaneous depol. rate HR SNS NE SA node (AV node) Na + “leak” rate time to threshhold HR spontaneous depol. rate ii) hormonal control SNS EPI/NE adrenal glands SA node (AV node)
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5. Regulation of blood flow - Heart and Vasculature 17 Where is CO going?
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This note was uploaded on 12/13/2010 for the course HK 3940 taught by Professor Murrant during the Fall '10 term at University of Guelph.

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5 Blood flow Heart - Negative feedback regulation OVERRIDE COORDINATING CENTRE SENSOR EFFECTOR negative feedback 5 Regulation of blood flow Heart

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