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Unformatted text preview: UKM Bangi, Selangor, Malaysia 2 School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia E-mail: firstname.lastname@example.org The study of transition metal complexes of thiosemicarbazones is of great interest due to their potential therapeutic activities, such as antitumoral, antifungal, antibacterial and antiviral. Cadmium and palladium complexes of 2-acetylbenzothiophene 4-methyl-3-thiosemicarbazone have been prepared. Characterization and structure elucidation of the complexes was achieved by elemental analysis (C, H, N 13 and S), IR, H-NMR, C-NMR (in the case of Pd(II) complex), UV and molar conductance. The results indicate the formation of 1:2 metal to ligand complexes with empirical formula [Cd(BTMTS) 2] and [Pd(HBTMTS)2Cl2], (HBTMTS = thione form of the 2-acetylbenzothiophene 4-methyl-3thiosemicarbazone ligand; BTMTS = thiol form of the ligand). The cadmium complex is four coordinated and is proposed to have tetrahedral geometry. On the other hand, palladium complex is six coordinated and is proposed to have octahedral geometry, where the ligand behaves as a bidentate N, S chelating agent. In vitro antimicrobial studies showed that the [Cd(BTMTS)2] complex had a strong inhibitory action, as compared to Tobramycin, against G(+) Bacillus subtilis and G(+) Staphylococcus aureus. The [Pd(HBTMTS)2Cl2] complex however, showed weak inhibitory action. The cadmium complex showed strong antifungal activity against Aspergillus fumigatus, Aspergillus niger and Candida parapsilosis. The antifungal activity of the cadmium complex was even better than commercially available Nystatin. The palladium complex did not inhibit the growth of the tested fungi. 1 INO-P6 ANALYSIS OF HETEROCYCLIC TETRAORGANOTIN COMPOUNDS BY INDUCTIVELY COUPLED PLASMAMASS SPECTROMETRY Quai Ling Yap and K.M. Lo Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia E-mail: email@example.com Inductively coupled plasma-mass spectrometer (ICP-MS) was commercially introduced...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.
- Spring '11