18 12 11 1 oh 17 16 15 20 21 10 5 9 h 8 13 14 2 r1 r2

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: tion. With emerging evidence for the importance of Icmt-catalyzed CaaX protein methylation in oncogenesis, the development of Icmt inhibitors is a new approach to find anticancer drugs. In the current studies, the first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished in an overall high yielding reactions sequence. 197 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia ORG-P2 SYNTHESIS OF 2,3-DIHYDRO-4-PHENYL-2- (4(PYRIDINE-2YL) PHENYL) BENZO [B] THIAZEPINE Naval, R.M. Department of Chemistry, Jijamata College of Science and Arts, Dnyaneshwarnagar, Bhende.Tal- NewasaDist- Ahmednagar, Maharashtra, India - 414 605 E-mail: rameshnaval@gmail.com Benzothiazepinesare are well-known for their broad spectrum of biological and pharmacological activities such as calcium channel antagonism, neuroleptic, antipsychotic agent, antidepressant, anticonvulsant and antitumor activity. Due to their immense medicinal importance, there is a never growing demand for the synthesis of new and newer thiazepines. Taking these facts in to consideration, in the present investigation, an attempt was made to synthesize 2,3 -dihydro-4-phenyl-2- (4(pyridine-2yl) phenyl) benzo [b] thiazepine employing environment friendly techniques like ultra -sonication and microwave techniques. 2,3-dihydro-4-phenyl-2- (4(pyridine-2yl) phenyl) benzo [b] thiazepinewas successfully synthesized by treating the chalcone,1-phenyl-3-(4-(pyridine-2-yl)-phenyl)prop-2-en-1-one with 2-amino thiophenol, taken in to a 50 mL beaker with 10 mL gl. acetic acid. The reaction mixture was irradiated inside a microwave oven for 3 to 5 min at an output of 300 watts power, with short interruption of 15 seconds. Progress of reaction was monitored by the TLC. Product was separated by filtration and crystallized from ethanol to afford 2,3-dihydro-4-phenyl-2- (4(pyridine-2yl) phenyl) benzo [b] thiazepine. The compound thus synthesized was characterized using NMR, IR and mass spectroscopy. ORG-P3 SYNTHESIS AND MESOMORPHIC BEHAVIOR OF NEW BENZOXAZOLE-BASED LIQUID CRYSTALS 1 *Sie-Tiong Ha, Kok-Leei Foo, Teck-Leong Lee, Guan-Yeow Yeap and Peng-Lim Boey 2 2 3 3 Department of Che...
View Full Document

This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

Ask a homework question - tutors are online