Acute toxicity test had been carried out in vivo and

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Unformatted text preview: homas I.A. Gerber, Peter Mayer and Nonzaliseko C. Yumata 1 2 1 1 Department of Chemistry, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031, South Africa 2 Department of Chemistry, Ludwig-Maximilians University, D-81377 München, Germany E-mail: Abubakr.Abrahams@nmmu.ac.za There is currently considerable interest in the coordination chemistry of rhenium, mainly because of the 186/188 potential applications of its Re radionuclides in radiotherapy. The main focus is on the +I, +III and +V oxidation states of the metal, since they are easily obtained from the reduction of perrhenate and are stabilized by a large variety of ligands. Schiff base comple xes of rhenium(I), (III) and (V) have been well studied, and several comprehensive reports have appeared in the litera ture during the last 30 years. Most of the ligands were of the {(hydroxy/mercapto)phenyl}salicylideneimine type, and a few were synthesized from acetylacetone derivatives and amines. We have studied the reactions and product formation of the tridentate Schiff bases 6 -amino-3-methyl-1-phenyl-4-azahept-2-ene-1-one (Hamp), obtained from the condensation of 1-benzoylacetone and 1,2-diaminopropane, and 7-amino4,7-dimethyl-5-aza-3-octen-2-one (Hada), from 2,4-pentanedione and 1,2-diamino-2-methylpropane, with trans-[ReOCl3(PPh3)2], trans-[ReCl3(MeCN)(PPh3)2] and [Re(CO)5Br]. The syntheses, characterization and X-ray crystal structures of (-O)[ReOCl(amp)]2, cis-[ReCl2(bat)(PPh3)2] (bat=1-benzoylacetone) and [Re(CO)3Br(Hada)] will be reported and discussed. R1 O R1 O NH H3C R2 NH2 H3C CH3 N N H2 R2 CH3 (a) (b) R1 OH N H3C R2 NH2 CH3 (c) R1 R2 C6H5 H Hamp CH3 CH3 H ada Scheme 1 Schematic representation and tautomerization of the ligands. 134 3rd ICYC 2010 Universiti Sains Malaysia INO-P5 23rd-25th June 2010 SPECTRAL AND ANTIMICROBIAL STUDIES OF CADMIUM(II) AND PALLADIUM(II) COMPLEXES OF 2 ACETYLBENZOTHIOPHENE 4-METHYL-3 THIOSEMICARBAZONE 1 Safa’a Faris Kayed, Yang Farina, Ibrahim Baba and Nazlina Ibrahim 1 1 2 School of Chemical Sciences and Food Technology, Faculty of Science and Technol ogy, Universiti Kebangsaan Malaysia, 43600...
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