Among the four extracts the hexane fraction showed

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Unformatted text preview: te fraction showed good antioxidant activity in DPPH assay among all the fractions with IC50 of 0.215 mg/mL and it also showed highest phenolic content in comparison with to all the extract and fractions. However, the ethyl acetate fraction showed less activity as compared with the standards, BHA and Ascorbic acid (0.011 mg/mL and 0.015 mg/mL). Meanwhile, methanol and water extracts of the plants showed no effect against cancer cells with IC 50 > 100 µg/mL. However, the methanol extract showed good antioxidant activity in -carotene bleaching assay with antioxidant activity of 66.06 ±0.63 % at 4 mg/mL. Meanwhile, the extracts from this plant exhibited weak activity against the normal cell line, MRC-5 (44.2 µg/mL). The result of this study suggests that Alpinia pahangensis can be further investigated for consumption as antioxidant and treatment for cancer. NAT-P19 THE CYTOXICITY AND ALKALOID STUDIES OF CATHARANTHUS ROSEUS (APOCYNACEA) LEAVES WITH PROFILING BY LCMS S.H.Tiong, Hazrina Hazni and Khalijah Awang Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia E-mail: kingdom86_@hotmail.com The preliminary cytoxicity studies of Catharanthus roseus hexane extract showed about 85, 78, 71, 71 and 62 % cell viability at 80 μg/mL for CaSki, HSC 2, MCF 7, HepG 2 and PC -3 cell lines, respectively. The isolation and structural determination of the alkaloid successfully isolated from the hexane crude till now was described. The study afforded vindoline till now and further work is still in progress. The structure was determined by NMR and MS with reference to the literature. The LCMS profile of the hexane extract will also be presented. 180 3rd ICYC 2010 Universiti Sains Malaysia NAT-P20 23rd-25th June 2010 ALKALOIDS ISOLATED FROM THE BARK OF LITSEA GRANDIS AND LITSEA LANCIFOLIA (LAURACEAE) Syazreen Nadia Sulaiman, Khalijah Awang, A.Hamid A.Hadi and Mat Ropi Mukhtar Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia E-m...
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