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Unformatted text preview: of Science, King Abdul Aziz University, 80203, Jeddah, 21589, Kingdom of Saudi Arabia E-mail: firstname.lastname@example.org Some more new Sulfur compounds bearing heterocyclic systems mainly 2 -thioxo-1,3,4-thiadiazinone derivatives 2-7 and or 3-thioxo-1,2,4-triazole derivatives 9 have been synthetic via alkylation, acylation and or condensation of dithioic formic acid hydrazide 1 through ring closure reactions with α,β -bi functional groups compounds . Most of the obtained target showed a highly activity towards some microbial in compare with two references antibiotics, Pipercillin and Mycostatine. The structures of the products have been established from their elemental and spectral analysis.
CH2Cl CH2Cl S ClCH2COOH
H2NNH SH DMF
H N S 1
NH S COOEt COOEt NaOAc/EtOH ClCOCH2Cl DMF
Cl COOMe CH COOMe O H N S NH S 7 THF 2
H N O S O O H N S DMF
NH S H N H NH S S Dry C6H6 NH S 6
O MeOOC NH2 O Cl O N H S S 3 5 4 204 3rd ICYC 2010 Universiti Sains Malaysia ORG-P15 23rd-25th June 2010 SYNTHETIC OF SOME MORE SULFUR COMPOUNDS BEARING HETEROCYCLIC SYSTEMS AS BIOCIDAL AGENTS-PART II: SYNTHETIC OF 2-THIOXO THIAZOLE/THIA DIAZOLE AND 3 -THIOXO-1,3,4-TRIAZOLE DERIVATIVES Mohammed S.T. Makki, Abeer N. Al-Romaizan and *Reda M. Abdel-Rahman Chemistry Department, Faculty of Science, King Abdul Aziz University, 80200 Jeddah, 21589, Kingdom of Saudi Arabia E-mail: email@example.com Some more new 2-thioxo thiazole , 2-thioxo thiadiazole and 3-thioxo-1,3,4-triazole derivatives 3-17 have been synthesized from ring closure reactions of dithioic formic acid hydrazones 2 with α,β-bi functional reagents in different medium . Former structures of the products have been established by the help of elemental and spectral analysis. Most of the obtained targets showed a moderate activity towards some microbial in comparizon with two antibiotics Pipercillin and Mycostatine.
S H2NNH SH R Ar N N H S SH COOEt COOEt g EtOH 2 a-Q THF e
S S R Ar N H N NH HS NH S R Ar N N S O 16
R`= CH3, Ph H2NCH2CH2OH R`-CONHNH2 EtOH Fusion Ar`NH2 O 10 Fusion -H2S
H N N S R Ar N NH R S Ar S H N S NH O R Ar N N NH R...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.
- Spring '11