Among them halogenated witting reagent has been used

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: of Science, King Abdul Aziz University, 80203, Jeddah, 21589, Kingdom of Saudi Arabia E-mail: as-lili@hotmail.com Some more new Sulfur compounds bearing heterocyclic systems mainly 2 -thioxo-1,3,4-thiadiazinone derivatives 2-7 and or 3-thioxo-1,2,4-triazole derivatives 9 have been synthetic via alkylation, acylation and or condensation of dithioic formic acid hydrazide 1 through ring closure reactions with α,β -bi functional groups compounds . Most of the obtained target showed a highly activity towards some microbial in compare with two references antibiotics, Pipercillin and Mycostatine. The structures of the products have been established from their elemental and spectral analysis. CH2Cl CH2Cl S ClCH2COOH H2NNH SH DMF H N S 1 NH S COOEt COOEt NaOAc/EtOH ClCOCH2Cl DMF Cl COOMe CH COOMe O H N S NH S 7 THF 2 H N O S O O H N S DMF NH S H N H NH S S Dry C6H6 NH S 6 O MeOOC NH2 O Cl O N H S S 3 5 4 204 3rd ICYC 2010 Universiti Sains Malaysia ORG-P15 23rd-25th June 2010 SYNTHETIC OF SOME MORE SULFUR COMPOUNDS BEARING HETEROCYCLIC SYSTEMS AS BIOCIDAL AGENTS-PART II: SYNTHETIC OF 2-THIOXO THIAZOLE/THIA DIAZOLE AND 3 -THIOXO-1,3,4-TRIAZOLE DERIVATIVES Mohammed S.T. Makki, Abeer N. Al-Romaizan and *Reda M. Abdel-Rahman Chemistry Department, Faculty of Science, King Abdul Aziz University, 80200 Jeddah, 21589, Kingdom of Saudi Arabia E-mail: as-lili@hotmail.com Some more new 2-thioxo thiazole , 2-thioxo thiadiazole and 3-thioxo-1,3,4-triazole derivatives 3-17 have been synthesized from ring closure reactions of dithioic formic acid hydrazones 2 with α,β-bi functional reagents in different medium . Former structures of the products have been established by the help of elemental and spectral analysis. Most of the obtained targets showed a moderate activity towards some microbial in comparizon with two antibiotics Pipercillin and Mycostatine. S H2NNH SH R Ar N N H S SH COOEt COOEt g EtOH 2 a-Q THF e S S R Ar N H N NH HS NH S R Ar N N S O 16 R`= CH3, Ph H2NCH2CH2OH R`-CONHNH2 EtOH Fusion Ar`NH2 O 10 Fusion -H2S H N N S R Ar N NH R S Ar S H N S NH O R Ar N N NH R...
View Full Document

This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

Ask a homework question - tutors are online