For this purpose the synthesized dimer has been used

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Unformatted text preview: R. Miri, M. Vosooghi and *A. Shafiee 1 2 3 4 4 Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran Department of Pharmacology, Tehran Medical Unit, Islamic Azad University of Medical Sciences, Tehran, Iran 3 Medicinal and Natural products Chemistry Research centre, Shira z University of Medical Sciences, 71345 Shiraz, Iran 4 Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Tehran 14174,Iran E-mail: [email protected] 2 A series of alkyl, cycloalkyl, and aryl esters of nifedipine in which the o-nitrophenyl group at position 4 is replaced by 2- [(2-chlorophenyl) and (3-chlorophenyl)]-4-thiazolyl substituent were synthesized and evaluated for their calcium channel antagonist activities usin g isolated ileum of guinea pig. The anticonvulsant activity of test drugs was also assessed in pentylenetetrazole (PTZ) -induced seizure in male Naval Medicinal Research Institute (NMRI) mice model. The results showed that although all compounds were at least 100 times less active than the reference drug nifedipine in terms of calcium channel antagonist activity, nevertheless all compounds showed considerable anticonvulsant activity. 202 3rd ICYC 2010 Universiti Sains Malaysia ORG-P12 23rd-25th June 2010 AN APPROACH FOR STILBENES VIA PALLADIUM-CATALYZED HECK COUPLING OF ARYL HALIDES WITH OLEFINS 1 Munirah Suhaimi, Mohamad Nurul Azmi, Kee Chin Hui, Kartini Ahmad, Noel F. Thomas and 1 Khalijah Awang 1 2 1 3 1 2 Department. of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia Centre for Natural Product Research and Drug Discovery (CENAR), Department. of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia 3 Department of Chemistry, Faculty of Science and Technology, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia E-mail: [email protected] The search of new methods for the construction of organic molecule from simple starting materials is an ongoing challenge for the organic chemist. Palladium-catalyzed reaction of vinyl or aryl halide with alkene (Heck reaction) has been subje...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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