In nature some of these biomolecules except

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Unformatted text preview: ic separation can be performed in three modes, i.e. by forming diastereomer / derivatization of samples, or by adding chiral selectors to the mobile phase, or the most popular type, by using chiral stationary phases (CSPs). Up till now, a great number of CSPs have been developed and are commercially available; there are CSPs which are modified with cyclodextrins (CDs), CD derivatives, proteins, crown-ethers, polysaccharides, macrocyclic antibiotics, the Pirkle-type phases (chiral recognition occurs at binding sites), and etc. However, none of these CSPs can be considered universal, i.e. has the ability to separate all classes of chiral compounds , and the preparation procedures are rather time-consuming and complicated. In this paper, we focused on the use of commercially available CD derivatives (especially β-CD or γ-CD), which can be easily bonded onto silica gel stationary phases, for the separation of dansyl amino acids in capillary LC using both packed and monolithic capillary columns. 57 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia KN-19 APPLICATIONS OF DOMINO REACTIONS IN ORGANIC SYNTHESIS S.Perumal School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India E-mail: subbu.perum@gmail.com ‘Domino’ reactions are one pot processes involving two or more reactions occurring in sequence. These reactions are also known as ‘cascade’ or ‘tandem’ processes. Nature employs domino reactions in building several complex molecules. Since all the reactions occur in one pot, all of them need to have comparable activation energies. The products of intermediate steps are usually not isolated and purified in this synthetic protocol. Hence waste disposal is kept minimal in these processes thereby saving a lot of solvent, adsorbent, etc. and the yield of the final product is maximized. Thus this synthetic protocol is eco-friendly and green. As several reactions occur in one pot, this protocol usually provides a rapid access to complex molecules, thus rendering the synth...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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