In syntheses approach biotransformation is widely

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Unformatted text preview: theses tool. Balanolcarpol considered as a polyphenol esp ecially made up of a dimer it has been found that balanocarpol exhibits modest HIV inhibitory activity in the antiviral assay on the other hand goniothalamin isolated from Goniothalamus exhibit cytotoxic and antitumor activity. Mesterolone is used to balance the deficiency of androgen formation, which begins to fall gradually with increasing age and it is therefore suitable for the treatment of all conditions caused by deficient endogenous androgen formation. Further anti-inflammatory bioassay studies on mesterolone have shown it to be a safe and effective drug. In view of the foregoing biological activities of above mentioned compounds microbial transformation was carried out in order to obtain new and more potent derivatives of these compounds. 12 selected fungi from Malaysian endophytes and ATCC cultures that were used in prednisolone modification are HAB10R12, NW30, HAB11R3, 11L2, HAB2R1, C albicans, M.plumbus, V.alphadicola, B.cinerea, A.niger, C.elegans, R.stolonifer and mixed cultures of R.stolonifer/C.ellegans. These fungi were maintained and grown in specific media and fermented on an incubated shaker at 85 rpm, 27-29 °C. As a result of fermentation of above mentioned compounds, few transformed products are identified with the help of chromatographic and HPLC analysis. These transformed products will be further subjected to advance spectroscopic techniques like 1D and 2D-NMR for structure confirmation. 187 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia ORG-O7 NEW MUTANTS OF THERMOANAEROBACTER ETHANOLICUS SECONDARY ALCOHOL DEHYDROGENASE IN ASYMMETRIC SYNTHESIS OF PHENYL-RING-CONTAINING ALCOHOLS 1 Musa M. Musa and Robert S. Phillips 2 1 Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia 2 Chemistry Department, University of Georgia, Athens 30602, USA E-mail: [email protected] HS HR CONH2 Re face O R2 R 1 HS Si face N HR CONH2 OH (R) R1 R2 OH (S) R1 R2 N ADPR...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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