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Unformatted text preview: ere compared with interim national water quality standards for Malaysia and found that the soil and water quality of area is degraded so it is concluded that Bestari Jaya ex-mining catchment has a high pollution potential due to mining activities and Sungai Ayer Hitam, recipient of catchment water is a highly polluted river. Different environmental aspects have also discussed in t his paper for the future research during this project. 104 3rd ICYC 2010 Universiti Sains Malaysia ENV-P5 23rd-25th June 2010 ANTI-INFLAMMATORY AND ANTINOCICEPTIVE ACTIVITIES OF ETHANOL EXTRACTS FROM DATURA METEL Marie Christine Merca-Obusan Institute of Environmental Science and Meteorology, University of the Philippines, Diliman, Quezon City, Philippines Department of Science and Technology, Philippine Science High S chool-Bicol Region Campus, Goa, Camarines Sur, Philippines E-mail: [email protected] The growing demand for natural sources of agents used in the manufacture of drugs demands the evaluation of phytochemicals for bioactivity. This work screened ethanol extracts from the seeds of Datura metel, a plant known to contain alkaloids, for anti -inflammatory and antinociceptive activities in albino rats. Substance extraction, preliminary toxicity evaluation, formalin -induced inflammation assay, and phasic thermal stimulus nociception test were done. The anti -inflammatory parameters were % inflammation and % inhibition based on differential paw sizes measured between observation periods. Inhibition of acute pain perception was observed in terms of latency to the given stimulus compared with the standard latent time reaction for normal nociception. Significant differences in the parameters measured among the control (positive= +C or negative= -C) and the different samples treated were determined by One-Way ANOVA. Scheffe's test was employed for identification of significant contrasts. Major findings were : i)The maximum non-fatal dose of ethanol extracts was 90 % at 1000 mg/kg; ii) All treatment concentrations (20, 50 and 70 %) administered intraperitoneally at 1000 mg/kg...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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