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Unformatted text preview: vents were removed under reduced pressure and the extracts were analyzed for ant ioxidant activity by free radical DPPH scavenging and β-carotene bleaching assay, total phenolic contents by Folin-Ciocalteu method and toxicity by brine shrimp lethality test (BST). The ethanol extract of fresh and dry leaves showed the highest antioxidant activity against DPPH radicals and β-carotene bleaching assay. The total phenolic contents were ranging from 23.33 - 54.74 mg gallic acid equivalent per 1 g extract. The petroleum ether extract of fresh and dry leaves showed positive response to BST at higher concentration of 1000 µg/mL after 12 hrs. NAT-P11 ISOLATION OF ANTHRAQUINONES FROM PRISMATOMERIS GLABRA Ratni Suriyani, J. Humera Naz, J.F.F. Weber and A. Aishah Institute for the Study of Natural Remedies (iKUS), Faculty of Pharmacy, University Technology MARA, 42300 Puncak Alam, Selangor, Malaysia E-mail: ratni_suriyani@yahoo.com The genus Prismatomeris (Rubiaceae) includes about 29 species growing in tropical areas. Phytochemical studies on this genus showed the presence of iridoids, anthraquinones and triterpen es. A water decoction of the roots of P. fragrans is traditionally used by people in Thailand as tonic. An aqueous extract of the roots of P. malayana was used as an adjunct in dart poison in Malaysia. Antrhaquinones isolated from this species exhibited antiplasmodial, antimycobacterial, antifungal and anticancer activities against BC and NCI-H187 cell lines. P. glabra is used as an energy booster in some parts of Malaysia. Yet, no phytochemical work on has ever been reported for this species. Chemical studies on methanolic extract of this plant led to the isolation of few anthraquinones. The structures 1 13 were determined by spectrometric analysis including H-NMR, C-NMR and MS. O R1 R2 R3 O R4 176 3rd ICYC 2010 Universiti Sains Malaysia NAT-P12 23rd-25th June 2010 HPLC-SCREENING METHOD FOR GENERAL SCREENING OF MICROBIAL METABOLITES FROM MALAYSIAN RAIN FOREST SOIL FUNGI 1 Siti Hajar Sadiran, Jean-Fr...
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