Org o13 synthesis of biologically active coumarin

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Unformatted text preview: urring compounds found throughout the plant kingdom, while aminothiazol and its derivatives also have pronounced pharmacological activities. An effort is made to synthesize the potential biologically active compounds based on the combination of different substructures in order to increase their biological activity. Coumarin derivatives having aminothiazole moiety 3-(2-(2-benzylidene)hydrazinyl)thiazol-4-yl)-2H-chromen-2-one were synthesized by Hantzsch reaction of different substituted benzylidene thiosemicarbazides with 3 -(ωbromoacetyl)coumarin. This study reports the synthesis, characterization and in vitro antibacterial, antifungal and antioxidant activities of the above mentioned compounds. Structures of all compounds were elucidated by IR, 1D and 2D NMR spectroscopy and ma ss spectrometry. Antibacterial activity of the coumarin derivatives was evaluated by using Gram positive and Gram negative bacteria, while antifungal activity was tested against Candida albicans. The compounds were also investigated for antioxidant activity by using DPPH radical assay. 191 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia ORG-O14 SYNTHESIS, CHARACTERIZATION AND SOL-GEL EXTRACTION OF METAL ION WITH 1[(BROMOMETHYL)(PHENYL)METHYL]-2-(2,4-DINITROPHENYL)HYDRAZINE Norfarhah Abdul Razak, *Abdussalam Salhin Mohamed and Ismail Ab Rahman School of Chemical Science, Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia E-mail: [email protected] Hydrazone compound, C14H11BrN4O4 have been synthesized and characterized by spectroscopic techniques (IR, CHN and H NMR). From the X-ray structure, the compound comprises two crystallographically independent molecules in the asymmetric unit. Sol -gel matrix containing physically immobilized hydrazone compound as metal ion sorbent was synthesized for the extraction of several metal-ions. The effect of extraction parameters such as pH, contact time and concentration of metal ion was examined. The sol-gel sorbent shows high selectivity towards copper, silver and iron metal ions...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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