Oth o2 effect of varing levels of n 6 n 3 fatty acid

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Unformatted text preview: r was available ad libitum. Pregnant rats were killed 15 days post mating and blood samples were taken. Rat plasma were analyzed for fatty acid profile s pecifly the % n3:n6. In addition, prostaglandin F2 α and E2 were also analayzed. The n-3 PUFA fatty acids profile of plasma after 8 week trial were significantly higher in rats fed cod liver oil than in those fed soybean oil, while the n-6:n-3 fatty acid ratio was significantly lower in plasma of rats fed cod liver oil than in those fed soybean oil. The total n-6 PUFA was significantly higher in rats fed soybean oil than in rats fed cod liver oil. Total PGF2 and PGE2 were higher in rats fed soybean oil comp ared to those fed cod liver oil, especially with higher levels of soybean oil. Higher levels of soybean oil in the diet appear to increase arachidonic acid and prostaglandins synthesis in plasma of rats. In the plasma a significant positive correlation was observed between arachidonic acid and prostaglandin synthesis. The n-6:n-3 fatty acid ratio significantly affected plasma fatty acids profile and prostaglandin synthesis in pregnant rat. 235 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia OTH-O3 SELF-ASSEMBLY FORMATION OF PALM-BASED ESTERS NANO-EMULSION: A MOLECULAR DYNAMICS STUDY 1,2 Mohd. Basyaruddin Abdul Rahman, Qiu-Yi Huan, Bimo A. Tejo, Mahiran Basri, Abu Bakar Salleh 3 and Raja Noor Zaliha Abdul Rahman 2 2 2 3 1 2 Structural Biology Research Center, Malaysia Genome Institute, 43600 UKM Bangi, Selangor , Malaysia Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia 3 Laboratory of Industrial Biotechnology, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia E-mail: basya@science.upm.edu.my Palm-oil esters (POEs) are unsaturated and non-ionic esters that can be prepared by enzymatic synthesis from palm oil. Their nano-emulsion properties possess great potential to act as drug carrier for transdermal drug delivery system. A ratio of 75:5:20 (water/POEs/Span20) was chosen from homogenous region in the phase diagram of our previous experi...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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