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Unformatted text preview: , infrared, conductance measurements and nuclear 1 13 magnetic resonance ( H NMR and C NMR) spectral data. From the spectral measurements, monomer structures for the complexes were proposed. Bidentate and Octahedral geometry was proposed for the complexes prepared. INO-P3 CYTOTOXICITY OF INDOLE SCHIFF BASE AND THEIR COPPER(II) AND NICKEL(II) COMPLEXES SJ Nazzatush, MA Hapipah, AA Mahmood, W Zin-Hua and AK Habsah Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia Department of Molecular Medicine, Faculty of Medicine, University of Mala ya, 50603 Kuala Lumpur, Malaysia Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia E-mail: nazshija@yahoo.com Schiff base compounds are known for their excellent bioactivities and are widely used in m ost pharmaceutical lines. While indole is one of the most abundant alkaloid present naturally in most plants and it also serves as good therapeutic agents in either physiological or pharmacological field. In this study, we synthesized indole hydrazone derivatives and their complexes and evaluated their cytotoxicity effect. Before any test could be carried out, the compounds were characterized carefully since molecular structures are important in determining the efficacies of each compound on the particular bioactivity. Cytotoxicity tests were carried out on several cancer cell lines such as HCT 116, MDA -MB435, KB and MCF-7. Some compound especially compounds containing chlorine and bromine were found to be effective as anti-cancer agents at a concentration less than 20 μg/mL. Acute toxicity test had been carried out in vivo and it showed no sign of mortality within 24 hours. Further observation was done and the mice were found to be alive and active. 133 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia INO-P4 COORDINATION BEHAVIOUR OF ACETYLACETONE-DERIVED SCHIFF BASES TOWARDS RHENIUM(I), RHENIUM(III) AND RHENIUM(V) 1 Abubak’r Abrahams, T...
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