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Unformatted text preview: 9 Karnataka, India E-mail: [email protected] In recent decades, problems of multi-drug resistant microorganisms have reached on alarming level in many countries around the world. Infections caused by those microorganisms pose a serious challenge to the medical community and the need for an effective therapy has led to a search for novel antimicrobial agents. Quinoline is a heterocyclic base which has attracted the attention of organic chemists for more than 150 years. Quinoline ring system is present both in the natural products and synthetic compounds of biological interest. Quinoline ring fused with five or six member heterocyclic ring containing one or two heteroatoms is also found in the natural products as well as in the synthetic compounds of biological interest. Quinolines and their derivatives are receiving increasing imp ortance due to their wide range of biological activities as anti -malarial, anti-bacterial, anti-asthmatic, antihypertensive, anti-inflammatory, anti-platelet activities. In this paper, the novel synthesis of quinoline five member heterocycles was reported. The reaction of 4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5c]quinoline with anthranilic acid which in turn cyclise in presence of POCl 3 to get the seven member ring in the target molecule. This is treated with different alkyl halides to get the derivativ es of target 1 molecule. The structure of all the newly synthesized compounds has been established by H NMR, IR, Mass and elemental analysis. The selected compounds have been screened for antimicrobial activities. 185 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia ORG-O3 METALLATION OF SOLOCHROME CYANINE R USING METALLATED AGENTS TO FORM COMPOUNDS HAVING ANTIMICROBIAL ACTIVITIES *Emtithal A. El-Sawi, Tahia. B. Mostafa and Mai A.Osman Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, Egypt E-mail: [email protected] Metallated solochrome cyanine R compounds were synthe...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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