Unformatted text preview: hman and K.O.Al-Footy Department of Chemistry, Faculty of Science , King Abdel Aziz University, P.O.Box 80203, Jeddah, 21589, Kigdom of Saudia Arabia E-mail: [email protected] Novel 1,2,4-triazolo[4,3-b][1,2,4]triazines (11-12) and 1,2,4-triazolo[4,3-b][1,2,4,5]tetrazines derivatives(16-20) have been obtained starting from reaction of 3-(pyridin-4-yl)-4-amino-5-arylamino1,2,4-triazole(10) and or 3-(pyridin-4-yl)-4-amino-5-hydrazino-1,2,4-triazole(15) with α,β-bifunctional compounds, chloromethyl diphenylphosphonic acid , phenacyl bromide, pyruvic acid, diethyl oxalate, triethyl phosphite, triethyl orthoformate, fluorinated benzaldehyde, ethyl chloroformate and carbon disulfide in different conditions and medium. Structure of the products has been elucidated from their elemental and spectral data. All targets obtained were evaluated as anti -inflammatory agents in compared with the standared drug Indomethacin, in addition, as well as antimicrobial agents .
N Ar N HN Ph P Ph OH N Ar ' N N N N N NH NH2 NH 2 N Ar N N N N N Ar ' Ar N O Me N P NH N Ar N N N HN NH S NH NH ORG-P9 SYNTHESIS AND CHARACTERIZATION OF 5-ACETYL-4- (4'-ALKYLOXYPHENYL)-3-CYANO-6-METHYLPYRIDINE-2-(1H) THIONES Elham A. Al-Taifi and Guan-Yeow Yeap Liquid Crystal Research Laboratory, School of Chemical Science s, Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia E-mail: [email protected] 4-Alkyloxybenzaldehydes (1) were reacted with 2-cyanothioacetamide (2) to afford 2-cyano-3-(4'alkyloxyphenyl)prop-2-enethioamides (3) which reacted subsequently with acetylacetone to give the corresponding 5-acetyl-4-(4'-alkyloxyphenyl)-3-cyano-6-methylpyridine-2(1H)-thiones (4). The target compounds 5-acetyl-4-(4'-alkyloxyphenyl)-3-cyano-6-methyl-2-alkylthiopyridine have been obtained via alkylation on compound 4 with bromoalkanes. The structure elucidation of thus synthesized heterocyclic 1 13 compounds was based on CHN microanalytical analyses, FTIR and NMR ( H and C). 201 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia ORG-P10 CALIXARENES DIM...
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