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Unformatted text preview: ICYC 2010 Universiti Sains Malaysia NAT-O5 23rd-25th June 2010 HEPATOPROTECTIVE ACTIVITY OF CAESALPINIA DIGYNA AGAINST CARBON TETRACHLORIDE INDUCED ACUTE LIVER DAMAGE IN RATS
1 Srinivasan R, Chandrasekar MJN and Nanjan MJ 2 2 1 Department of Pharmaceutical Chemistry, School of Pharmacy and Health Sciences, International Medical University, Kuala Lumpur-57000, Malaysia 2 TIFAC CORE – Herbal Drugs, J.S.S. College of Pharmacy, Ootacamund-643001, India E-mail:firstname.lastname@example.org Caesalpinia digyna (Family: Leguminosae) is a large, scandent, prickly shrub or climber, growing wild in the scrub forests of the eastern Himalayas. The plant is one of the ingredients of an indigenous formulation, “Geriforte”, which has been used as daily health tonic. The drug also exhibits antifatigue effect in rats. It is also used in diabetes. Chemical investigations of the plant have shown the presence of caesalpinine A, cellallocinnine, ellagic acid, gallic acid, bergenin, bonducellin, intricatinol and tannins. In our earlier studies, the methanolic extract of Caesalpinia digyna (CDM) root has shown potent in vitro and in vivo antioxidant activity. This prompted our interest to carry out the hepatoprotective investigations of CDM. The CDM when administered orally to male albino rats at 100, 200 and 400 mg/kg body weight for 7 days, prior to carbon tetrachloride (CCl4) treatment, caused a significant decrease (p <0.001) in the levels of serum aspartate amino transferase (ASAT), alanine aminotransferase (ALAT) and alkaline phosphatase (ALP) and significant increase ( p <0.001) in the levels of total protein (TP) in serum and liver in a dose dependent manner, when compared to CCl 4 treated control. The above results are comparable to the standard, silymarin. These results clearly indicate the strong hepatoprotective property of Caesalpinia digyna root. The study provides a proof for the ethnomedical claims and reported biological activities. The plant has, therefore, very good therapeutic potential. NAT-O6 ESSENTIAL OILS OF ZINGIBER SPEC...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.
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