The experiments have shown that the adsorption rates

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Unformatted text preview: gration of monomer from bulk solution to the interface. This suggests that kinetics effects are probably beginning to compete with diffusion -controlled transport mechanism. PHY-O6 SPECTRAL ANALYSIS AND MOLECULAR MODELLING STUDIES OF THEOPHYLLINE/BETA-CYCLODEXTRIN INCLUSION COMPLEXES 1,2 Marina Mokhtar and Rohana Adnan 1 2 School of Chemical Sciences, Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia Faculty of Applied Sciences, Universiti Teknologi Mara, 13500 Permatang Pauh, Malaysia E-mail: marimokh79@gmail.com 1 Theophylline, a drug important analeptic of cardiac muscle and play an important role in relaxing smooth muscle, is slightly water soluble. This study was aimed at improving the solubility of TPH by inclusion complex with beta cyclodextrin (bcd). Different preparati on methods such as physical mixture, kneading, freeze-drying and evaporation have been employed in this study. Different analytical techniques (DSC, FT-IR, TGA, NMR) have been utilized for a throughout investigation of the structural characteristics of such inclusion complexes, which exhibited distinct spectroscopic features and properties from both "guest" and "host" molecules. FT -IR spectra shows some shift especially in hydroxyl stretching which is confirm the interaction between TPH and bcd occurred. Th is complexation is also be investigate by molecular modeling using Gaussian in order to obtain the structure of the complexation with binding energies. 213 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia PHY-O7 PREPARATION AND CHARACTERIZATION OF LIPOSOMES FROM COCONUT PHOSPHOLIPIDS: PROSPECT OF UTILIZATION OF COCONUT PHOSPHOLIPIDS AS LIPOSOMES MATERIALS 1,2 D Hudiyanti, TJ Raharjo, Narsito and S Noegrohati 1 1 3 1 Department of Chemistry, Gadjah Mada University, Sekip Utara Kotak Pos BLS 21 Yogyakarta 55281 Indonesia 2 Department of Chemistry, Diponegoro University, Jl. Prof. Sudharto, SH. Semarang Indonesia 3 Faculty of Pharmacy, Gadjah Mada University, Yogyakarta 55281 Indonesia E-mail: dwi_hudiyanti@undip.ac.id The use of phospholipids as liposome ma...
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