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Unformatted text preview: (6.00 and 10.1 g/100 g), respectively. The tested Ocimum essential oils and main components exhibited excellent antioxidant activity as measured by DPPH free radical -scavenging ability, bleaching of β-carotene in linoleic acid system and inhibition of linoleic acid oxidation. The antiproliferative activity has been tested on breast cancer MCF-7 and prostate cancer LNCaP cell lines by the MTT assay. Essential oils of O. basilicum showed best antioxidant while O. sanctum exhibited best anti-proliferative activities. A significant variation in the biological activities was observed with respect to regions and species. 69 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia ANA-O13 OPTIMIZATION OF DIFFERENT CONDITIONS FOR THE EXTRACTION OF PHENOLICS FROM THE LEAVES OF FICUS RETUSA Aftab Ashraf, Farooq Anwar and Muhammad Zubair Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad E-mail: email@example.com Different techniques and parameters were optimized for the extraction of phenolics from t he leaves of Ficus retusa. Techniques used were orbital shaker, magnetic stirrer and ultrasonic bath. Different 0 solvent systems used were 50 - 100 % methanol with water. Temperature range was from 30 to 50 C 0 with difference of 5 C. The extracts obtained by using above mentioned techniques and parameters were investigated for there antioxidant activity by using different in -vitro antioxidant tests. On the basis 0 of this investigation, it is found that orbital shaker at 50 C by using 80 % methanol showed the best results. ANA-O14 BIOEQUIVALENCE OF TWO ORAL MONTELUKAST FORMULATIONS IN HEALTHY PAKISTANI SUBJECTS: A SINGLE DOSE, OPEN-LABEL, RANDOMIZED, TWO-PERIOD CROSSOVER STUDY
1 Mateen Abbas, Muhammad Nawaz, Awais Shaukat, Rakhshanda Nawaz and Sualeha Riffat 1 2 2 1 1 Quality Operation Laboratory (QOL), University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan 2 Department of Chemistry, University of Agriculture, Faisalabad, Pakistan E-mail: Hafizmateen2002@yahoo.com Montelukast (MKST) is a potent, selective and orally active antagonist of the cysteinyl, CysTL1, leukotriene receptor used for the treatment of asthma in children and adults. The relative bioavailability of montelukast sodium as compared with an established branded formulation has not b een reported in Pakistani population. However, before generic formulation is placed on the market, pha...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.
- Spring '11