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Unformatted text preview: RUCTURAL MODEL DESIGN OF XANTHONE COMPOUNDS AND ITS APPLICATION AS ANTIMALARIAL ACTIVITY
1 Amanatie, Jumina, Mustofa, M.Hanafi and Ria Armunanto 1 2 2 1 1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Gadjah Mada University, Yogyakarta, Indonesia 2 Faculty of Medicine Gadjah Mada University, Yogyakarta, Indonesia 3 P3K LIPI Serpong Tangerang, Indonesia E-mail: firstname.lastname@example.org Xanthones and their derivatives have been reported to exhibit inhibitory activities towards plasmodium falciparum. To provide deep insight into the correlation between inhibitory activities and structures of xanthones, linear regression method was employed to establish QSAR models for 16 xanthone derivatives that have diverse structures. The accuracy and predictive power of the proposed QSAR model were verified by semi empiric PM3 method, optimation, and va lidation. The result showed that the best model was model 3. ORG-P7 SYNTHESIS AND ANTI-INFLAMMATORY EVALUATION OF SOME MORE NEW 1,2,4-TRIAZOLO[3,4b]THIADIAZOLES AS AN ANTIMICROBIAL AGENTS- PART I F.M.Aqlan, R.M.Abdel-Rahman and K.O.Al-Footy Department of Chemistry, Faculty of Science , King Abdel-Aziz University, P.O.Box 80203, Jeddah, 21589, Kingdom of Saudia Arabia E-mail:email@example.com Some new 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles (2-9) have been synthesized from the interaction between 4-amino-3-(pyrid-4-yl)-5-mercapto -1,2,4-triazole (1) and α,β-bifunctional compounds such as triethylphosphite, trifluroacetamide, cyanamide, isothiocyanate, carbon disulfide and or fluorinated benzaldehyde in different conditions and medium. Structures of the products have been established from their elemental and spectral data. All the targets obtained were evaluated as anti -inflammatory agents in compared with the standard drug Indomethacin as well as antimicrobial agents.
N Ar N N S Ar N CF 3 N S P N N N O H 2N C CF3 P(O Et )3 N N N NH 2 N SH 1 NH 2 C N i ) Ar 'CH O i i) FeCl3 N Ar N N N Ar NH NH 2 N N N N S Ar ' 200 3rd ICYC 2010 Universiti Sains Malaysia ORG-P8 23rd-25th June 2010 SYNTHESIS AND ANTI-INFLAMMATORY EVALUATION OF SOME NEW 1,2,4-TRIAZOLO[3,4b][1,2,4]TRIAZINE AND ,2,4-TRIAZOLO[3,4-b][1,2,3,4]TETRAZINE AS AN ANTIMICROBIAL AGENTSPART II F.M.Aqlan, R.M.Abdel-Ra...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.
- Spring '11