The structure was determined by nmr and ms with

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Unformatted text preview: ail: Litsea, a genus belonging to the family of Lauraceae, is widely distributed in tropical Asia, Africa and America. Litsea grandis is a tropical tree that can be found in Hutan Simpan Bukit Berangi, Kedah which locally name as Medang daun lebar meanwhile Litsea lancifolia or locally known as Medang melukut was collected in Hutan Simpan Tembat Ulu Terengganu, Terengganu. Phytochemical studies on the bark of Litsea grandis and Litsea lancifolia have been carried out. The dichloromethane extracts of Litsea grandis and Litsea lancifolia produced eight alkaloids namely laurotetanine(1), reticuline(2), Nmethylisococlaurine(3), boldine(4), norboldine(5), actinodaphnine(6), pallidine(7) and Nallyllaurolitsine(8) respectively. The isolation and purification of the compounds w ere achieved by using CC and PTLC techniques. The structural elucidation was performed by spectral methods namely 1D and 2D NMR, UV, IR and ESI-TOF-MS. 181 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia NAT-P21 CHEMICAL CONSTITUENTS OF AGLAIA EXIMA 1 Loong Xe- Min, Khalijah Awang and Khalit Mohamad 1 2 1 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia E-mail: Aglaia exima belongs to Mahogany family (Meliaceae). Genus Aglaia is the largest genus of the subtropical and tropical angiosperm family Meliaceae, widely spread in the Indo - Malaysian region. Typically, the major compounds isolated from this genus are benzo[b]oxepines, bis amides, cyclopenta[b]benzofurans, cyclopenta[b]benzopyrans, lignans, pregnane steroids, sesquiterpenoids, and triterpenoids which have interesting biological activity such as anticancer, antitumor, antiviral, antibacterial, insecticides. Hence, a phytochemical study on Aglaia exima was conducted. 1 kg of leaves collected from Terengganu was dried and extracted using hexane, dichloromethane and meth...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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