Unformatted text preview: cted of much attention by organic chemist since it was first discovered by Heck in 1968. In the last two decades, it has rapidly developed into an important methodology for carbon-carbon bond formation. In addition, the Heck reaction has also been successfully applied to the total synthesis of many biologically active natural products. To the best of our knowledge, we reported a general Heck coupling reaction of a resorcinol substituted acetamidostilbene. The uncommon stilbenes, 10-acetamido-3,5-dimethoxystilbene, has been synthesized by Heck coupling 1 13 in three steps. The structures of these stilbenes were unambiguously confirmed by 1D ( H, C) and 2D NMR experiment, (COSY, HMQC, and HMBC). ORG-P13 A NOVEL WAY TO PREPARE WITTIG REAGENTS UNDER MICROWAVE IRRADIATION AND SYNTHESIS OF HALOGENATED STYRYLLACTONES Nik-Salmah Nik-Salleh, Suraya Zulkepli, Mazlin Mohideen, Mohd Zulkefeli Mat Jusoh, Jean-Frédéric Faizal Weber and *A. F. M. Motiur Rahman iKUS, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Puncak Alam, Selangor, Malaysia E-mail: [email protected] A number of Wittig reagents were synthesized using microwave irradiation and obtained quantitative yields. Various solvent has been applied to obtain high yielded Wittig product and found o tetrahydrofuran (THF) solution at 60 C for 30 min gave quantitative yields. Among them halogenated Witting reagent has been used for the synthesis of styryllactone derivatives. A number of halogenated styryllactone derivatives have been synthesized, a corresponding series of E/Z styryllactone isomers were obtained in good yields, and their biological activities now are in progress.
O X PPh3 MW irradiation 30 min, 60 oC THF PPh3X 2 steps R O R R 203 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia ORG-P14 SYNTHETIC OF SOME MORE SULFUR COMPOUNDS BEARIN G HETEROCYCLIC SYSTEMS AS BIOCIDAL AGENTS – PART I: SYNTHETIC OF 2-THIOXO THIADIAZINONE DERIVATIVES Mohammed S.T. Makki, Abeer N. Al-Romaizan and *Reda M. Abdel-Rahman Chemistry Department, Faculty...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.
- Spring '11