Com preparation of c glucoside via incorporation of

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Unformatted text preview: condensation reaction. All the synthesized compounds were characterized using FTIR, H, C and DEPT NMR. 196 3rd ICYC 2010 Universiti Sains Malaysia ORG-24 23rd-25th June 2010 ISOLATION OF BIOACTIVE COMPOUNDS FROM FUNGAL TRANSFORMATION Syed Adnan Ali Shah, Sadia Sultan and Jean-Frédéric Faizal Weber Institut Kajian Ubat Semulajadi (iKUS), Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia E-mail: [email protected] Structural transformations using biological agent is relatively a new route in organic synthesis . Such transformations may involve multienzymatic system and led to the changes at the centers that are chemically unreactive. Microorganisms are capable of converting a whole range of organic compounds into their modified derivatives. Most of the fungi ar e known to carry out hydroxylation, side-chain cleavage, dehydrogenation, biodegradation, mineralization and other miscellaneous reactions in vast array of organic molecules. Structural modification by fungi has been extensively applied in the productions of several therapeutically important molecules on commercial scale. A variety of new molecules are now widely used as antibacterial anti -inflammatory, diuretic, anabolic, anti-androgenic, progestational and anticancer agents. Compound 2 and 3 were obtained from fungal transformation of 17α-ethynyl steroids, exhibiting a potent inhibitory activity against the α-glucosidase enzyme. 18 12 11 1 OH 17 16 15 20 21 10 5 9 H 8 13 14 2 R1 R2 3 H 6 4 7 H 19 CH3 1. R1= R2= C=O, 2. R1= OH, R2= H 3. R1= H, R2= OH POSTER PRESENTATION (ORGANIC) ORG-P1 THE FIRST TOTAL SYNTHESIS OF APLYSAMINE 6, AN INHIBITOR OF ISOPRENYLCYSTEINE CARBOXY METHYLTRANSFERASE Nisar Ullah and Khaled M. Arafeh Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia E-mail: [email protected] The C-terminal isoprenylcysteine of CaaX proteins motif targets a variety of eukaryotic proteins to a series of post-translational modifications important for their localization and func...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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