Com the synthesis of triorganotin carboxylates with

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Unformatted text preview: ubstituent at the C=C bond of the cinnamates. The products isolated are the carboxylic acids with the general formula HOOCCH(X)CH(Y)C6H5-Z-p where X= Br, -OCH3; Y= Br; Z = -H, -CH3, -OCH3. In + one case, the ionic compound [p-ClC6H5CHBrCHBrCOO] [(CH3)2NC5H4NH] was obtained. The triorganotin 1 carboxylates and their bromination products were characterized by elemental analysis, infrared, H and 13 C nuclear magnetic resonance spectroscopies. The X-ray structures of five of the compounds namely, bis(4,4-dimethylaminopyridinium) 2,3-dibromo-3-(p-chlorophenyl)propionate bromide, tributyltin pchlorocinnamate, tricyclohexyltin cinnamate, tricyclohexyltin 2,3-dibromo-3-phenylpropionate and tribenzyltin p-nitrocinnamate were also determined by X-ray crystallography. In addition, ten selected triorganotin carboxylate C4 - C10, C14, P4 - P6 against human leukemia HL60 cells were investigated and compared with cisplatin. Generally, the triorganotin carboxylates exhibit strong cytotoxic activities in these preliminary studies. INO-P10 SYNTHESIS AND STRUCTURAL STUDY OF SOME SUBSTITUTED BENZYLTIN COMPLEXES Thy Chun Keng and Lo Kong Mun Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia E-mail:ckthy84@yahoo.com Tri- and diorganotin compounds are generally prepared by the redistribution reaction between a tetraorganotin and stannic chloride in molar ratio of 3:1 and 1:1, respectively. In this project, some substituted benzyltin compounds namely dibenzyltin dichloride, di( p-methylbenzyl)tin dichloride, di(pfluorobenzyl)tin dichloride, di(o-chlorobenzyl)tin dichloride and di(p-bromobenzyl)tin dibromide were synthesized by the direct synthesis method using substituted benzyl chloride and tin powder in toluene. These substituted benzyltin dichloride were subsequently reacted with several ligands such as triphenylphosphine oxide, pyrazole, benzyl sulfoxide, 1 ,10-phenanthroline, 8-hydroxyquinaldine, 8hydroxyquinoline, 4,4’-bipyridine, 2,2’-bipyridine, 2-amino-3-hydroxypyridine and dibenzoylmethane. The complexes were characterized by using IR spectroscopic technique and in the case of crystalline complexes, singl...
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