Edumy widespread use of antibiotics in clinical

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Unformatted text preview: tes with curry leaf, Murraya koenigii (L.) Spreng as it is consumed and utilized as folk medicine. Evaluation of bioactive compounds in Murraya koenigii L. was studied from the leaves from various state s of Peninsular Malaysia and Sabah. Investigation upon its essential oil via gas chromatography-mass spectrometry (GCMS) reveals the major chemical constituents are β-Caryophyllene (19.50 - 26.58 %) and α-Humulene (12.65 - 27.31 %). Presence of other finer chemical constituents such as α-Selinene (0.57 - 12.21 %), βSelinene (3.59 - 6.69 %), Nerolidol (1.89 - 2.79 %), Juniper Camphor (1.51 - 16.46 %), Aromadendrane (0.46 - 1.45 %) and Lavandulyl acetate (0.03 - 1.67 %), was also noted. Distinct profile with variation in chemical constituents according to locality was also noted. The antimicrobial activities of the crude extract of curry leaf were tested via well diffusion assay that resulted in potent positive activity against 1 2 four human pathogenic strains (Pseudomonas aurelis, Escherchia coli , Escherchia coli and Staphalococcus aureus). Profiling of crude extracts via High Performance Liquid Chromatography (HPLC) reveals the presence of three major compounds from the Sabah crude extract while five compounds from all the peninsular extracts and it was successfully isolated using HPLC semi -prep system. Currently, the chemical structures of these compounds are b een investigated using NMR techniques to elucidate their possible structure. A HPLC based standardization of its extracts using the identified secondary metabolites as markers are being investigated. 1 174 3rd ICYC 2010 Universiti Sains Malaysia NAT-P9 23rd-25th June 2010 NATURAL ANTICANCER AGENTS ISOLATED FROM MALAYSIAN ALPINIA CONCHIGERA GRIFF (ZINGIBERACEAE) 1 Mohamad Nurul Azmi, Lionel In Lian Aun, Ahmad Nazif Aziz, Eswary Thirthagiri, Halijah Ibrahim, 2 1 Noor Hasima Nagoor and Khalijah Awang 2 5 3 4 Centre for Natural Product Research and Drug Discovery (CENAR), Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia 2 Department of Genetics &amp...
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