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Unformatted text preview: sp3)C-B compounds (alkylboron compounds) readily cross-couple with organic electrophiles to give coupled products selectively in high yields. Recently, the (sp)C-B compounds (1-alkynylboron derivatives) have been also observed to react with organic electrophiles to produce expected cross-coupled products. Such coupling reactions offer several advantages: (1) ready availability of reactants (2) mild reaction conditions (3) water stability (4) easy use of the reaction both in aqueous and heterogeneous conditions (5) toleration of a broad range of functional groups (6) high regio- and stereoselectivity of the reaction (7) insignificant effect of steric hindrance (8) use of a small amount of catalysts (9) application in one-pot synthesis (10) nontoxic reaction (11) easy separation of inorganic boron compound As one of defects of the reaction, one would point out the use of bases. However, it could be overcome the difficulty by using suitable solvent systems and adequate bases. Consequently, these coupling reactions have been actively utilized not only in academic laboratories bu t also in industrial processes. In this lecture, the overview of the coupling reaction will be dis cussed to understand the outlines. Additionally, current topics of the reaction will be presented briefly. 41 23rd-25th June 2010 3rd ICYC 2010 Universiti Sains Malaysia KN -01 THE SYNTHESIS, STRUCTURE AND IMMUNE REGULATING PROPERTIES OF PHOSPHATIDYLINOSITOL MANNOSIDES 1 DS Larsen, BS Dyer, G. Singh-Gill, GD Ainge, GF Painter, M Denis and JL Harper University of Otago, Dunedin, New Zealand Industrial Research Limited, Lower Hutt, New Zealand 3 The Malaghan Institute of Medical Research, Wellington, New Zealand 4 AgResearch Limited, New Zealand E-mail:[email protected] 2 1 1 1 2 2 3 4 Phosphatidylinositol mannosides (PIMs), present in the cell walls of mycobacteria, are attracting a great deal of attention as they elicit a range of immune responses and constitute the biosynthetic precursors of lipomannan and lipoarabinomannan. PIMs act as agonists of Toll-like receptor 2 (TLR2) which is involved with innate immunity.St...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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