Kntuacir nowadays the direction of science and

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Unformatted text preview: some disadvantages such as the use of expensive or highly acidic catalysts, prolonged reaction times and in some cases unsatisfactory yields. D ue to importance of these compounds, the introduction of a milder, faster and more eco -friendly method together with higher product yields is required. We have developed a simple and efficient methodology for the high -yielding synthesis of amidoalkyl naphthols by one-pot three-component coupling of ß-naphthol, aromatic aldehydes and urea or amides in the presence of MCM-41-SO3H as catalyst under the solvent -free conditions. Simple work-up, high yields, short reaction times and using a reusable catalyst are advantages of this new methodology. We believe that the developed procedure can be utilized for large scale eco-friendly preparation of amidoalkyl naphthol derivatives. Scheme 1 Ar OH + A rC H O + R C O N H2 1 2 3 N HC O R OH MCM-41-SO3H neat, 120°C 4 206 3rd ICYC 2010 Universiti Sains Malaysia ORG-P18 23rd-25th June 2010 EFFICIENT SYNTHESIS OF SUBSTITUTED IMIDAZOLES UNDER SOLVENT-FREE CONDITIONS USING MCM41-SO3H AS A HIGHLY EFFICIENT SULFONIC ACID NANOREACTOR Ali Mohammad Amani, Fatemeh Abdollahi and Mostafa Fatollahi Department of Chemistry, Faculty of sciences, K.N.Toosi University of Technology, P.O.Box:15875-4416; Tehran, Iran E-mail: In recent years more attractive possibilities have emerged by the development of various new silica materials with ordered structure. One of the best -known examples is MCM-41, which is a structurally well-ordered mesoporous material. An additional possibility to develop acidic solids is the modification of the surface of suitable support materials, as the chemical functionalities of these materials can be uniformly modified by covalent anchoring of different organic moieties. In the present work MCM -41 was modified to covalently bonded sulfonic groups on the inside surface of the channels and provide the silica supported material with Brönsted acid properties. While several type...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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