Unformatted text preview: . ORG-O15 THE STEREOSELECTIVE SYNTHESIS AND CHARACTERIZATION OF SUBSTITUTED 02,10 3,8 10,14 DIAZAPENTACYCLO[12.3.1. .0 .0 ]OCTADECA-3(8),4,6 TRIENE-9,15-DIONES WITH THE CREATION OF TWO HETEROCYCLIC RINGS AND FIVE STEREOCENTRES UNDER MICROWAVE IRRADIATION
1 Raju Suresh Kumar, Hasnah Osman, Aisyah Saad, Subbu Perumal and Mohamed Ashraf Ali and 4 Rusli
1 2 1 2 3 4 School of Chemical Sciences, Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia School of Pharmaceutical Sciences, Universiti Sains Malaysia11800 Pulau Pinang, Malaysia 3 Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University Madurai 625021, India 4 Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Pulau Pinang, Malaysia E-mail: [email protected] An expedient, three-component, domino protocol for the synthesis of a series of substitu ted 02,10 3,8 10,14 diazapentacyclo[12.3.1. .0 .0 ]octadeca-3(8),4,6-triene-9,15-diones stereoselectively with the creation of two heterocyclic rings and five stereocentres in good to excellent yields under microwave 1 irradiation is described. The structural characterization of these compounds was made by FTIR, H and 13 C NMR spectrometry. 192 3rd ICYC 2010 Universiti Sains Malaysia ORG-O16 23rd-25th June 2010 CYTOTOXIC AND ANTI-TUBERCULAR ACTIVITIES OF SOME NOVEL PYRAZOLINE DERIVATIVES
1 Laxmana. K, D. Jagadeesh Prasad, G. V. Suresh Kumar, S. M. Chandrashekar Suresh P Nayak and 1 Boja Poojary
1 1 2 2 1 2 Department of Chemistry, Mangalore University, Mangalagangothri -574199, Karnataka State, India St. John’s College of Pharmacy, Department of medicinal chemistry, Vijanagara, Bangalore, Karnataka State, India-570040 E-mail: [email protected] A series of 1-2,3,4-trichlorophenyl-3-(4-aryl)-2-propene-1-ones were prepared by condensing arylaldehydes with 2,3,4-trichloroacetophenone in the presence of Potassium Hydroxide. These Propenones were treated with hydrazine hydrate and formic acid / acetic anhydride to obtain 5 -A...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.
- Spring '11