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Unformatted text preview: ructure-activity relationships of PIMs are complicated by the fact that these molecules exist in nature in multi-acylated forms and obtaining single entities from cell wall material is challenging. Although structures of the pseudo -oligosaccharide moieties of PIMs have been well established, those of the diacyl-glyceryl component are still unclear. Gilleron et al. concluded from their mass spectral data that PIM2 existed as a 62:38 mixture of two compounds with differing fatty acid acylation patterns, the major component contained a palmitate and ( R)-tuberculostearate (TBSA) residue bonded to the glycerol moeity. We have synthesised of a series of PIMs with differential acylation, and analogues with immune modulating properties that has determined the exact acylation pattern. The structure of 16:0; 19:0 PIM2 is 1. This paper will discuss the syntheses, structural analyses and biological activities of these molecules. 42 3rd ICYC 2010 Universiti Sains Malaysia KN-02 23rd-25th June 2010 APPLICATION OF THE BIOREFINERY CONCEPT: CONVERSION OF LIGNOCELLULOSICS TO BIOFUELS AND BIOMATERIALS Nicolas Brosse and Roland El Hage Laboratoire d’Etude et de Recherche sur le Matériau Bois, Faculté des Scien ces et Techniques, Bld des Aiguillettes, 54500 Vandoeuvre-lès-Nancy, France E-mail: [email protected] Lignocellulosic materials derived from agro-industrial activities offer a great opportunity for the development of environmentally benign technologies for the production of biofuels, green chemicals and biodegradable materials. However, the plant cell wall bears a very close association among its 3 main components (lignin, cellulose and hemicellulose) and this association limits the extent by which lignocellulosics can be utilized in industrial processes. Thus, the effective utilization of lignocellulosic biomass necessitates the development of pretreatment technologies which are ne cessary to separate them. One of the major goals of optimizing a pretreatment process is the full recovery of the feedstock through optimum utilization of all lignocellulosic components as marketable products. In this lecture, we will expo...
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This note was uploaded on 02/17/2011 for the course CHEMISTRY 101 taught by Professor Csr during the Spring '11 term at University of Louisville.

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