ATTFTT6I - New applications of LC-MS and LC-MS-MS toward...

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WEB version of article published in Trends in Analytical Chemistry, Vol. 24, No. 7, 2005 New applications of LC-MS and LC-MS-MS toward understanding the environmental fate of organometallics Tammy L Jones-Lepp, Georges-Marie Momplaisir Tammy L Jones-Lepp* U.S. Environmental Protection Agency Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division Las Vegas, Nevada United States of America Georges-Marie Momplaisir U.S. Environmental Protection Agency Office of Research and Development National Exposure Research Laboratory, Environmental Sciences Division Las Vegas, Nevada United States of America [Note: minor content and formatting differences may exist between this web version and the published version.] keywords: liquid chromatography, hyphenated mass spectrometric methods, LC-MS, LC-MS-MS, organometallics, organoarsenic, organoselenium, organotin, organoplatinum, organoboron *corresponding author
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WEB version of article published in Trends in Analytical Chemistry, Vol. 24, No. 7, 2005 2 Abstract Over the last 40 years, many organometallic compounds have been synthesized and used in a variety of consumer, agricultural, and industrial products. Including wastewater effluents, leaching, and direct land and water applications, there are many pathways that can disperse organometallics to the environment. Many of these compounds reach environmental compartments unchanged while others are transformed into chemical entities having different availability or toxicity to living organisms. Differences in the toxicological, biochemical, and environmental behavior of the various chemical forms of a trace- element often make the determination of the total element concentration inadequate. Considerable analytical progress in organometallic speciation has been made over the past decade, where hyphenated techniques involving highly efficient separation and sensitive detection have become the techniques of choice. Methods based on liquid chromatographic separation with mass spectrometric detection have revealed new organometallic compounds in environmental and biological matrices, contributing to a better understanding of biological effects and environmental fate of organometallics. This article surveys recent applications of liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography- mass spectrometry-mass spectrometry (LC-MS-MS) for the determination of organometallic compounds in environmental matrices.
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WEB version of article published in Trends in Analytical Chemistry, Vol. 24, No. 7, 2005 3 1.0 Introduction The use of synthetic organometallic compounds in consumer, agricultural, and industrial products has grown considerably over the last four decades. Many of these synthetic compounds are important in medicine (e.g., organoplatinum as neoplastic agents; organoboron in neutron capture therapy), household products (dibutyltin, dimethyltin, octyltin in plastic formulations), agriculture (triphenyltin,
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ATTFTT6I - New applications of LC-MS and LC-MS-MS toward...

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