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CHE_Toxicants_and_Disease_Database.160121218 - CHEMICAL...

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C HEMICAL C ONTAMINANTS AND H UMAN D ISEASE: A S UMMARY OF E VIDENCE Sarah Janssen, MD, PhD, MPH, University of California, San Francisco Gina Solomon, MD, MPH, Natural Resources Defense Council, University of California San Francisco Ted Schettler, MD, MPH, Science and Environmental Health Network, Boston Medical Center Supported by the Collaborative on Health and the Environment www.HealthandEnvironment.org. For questions or comments about the database, please contact Eleni Sotos at [email protected]
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Please note that the attached document is a spreadsheet version of the CHE Toxicant and Disease Database. The spreadsheet was created to provide a hard copy version to those without computers or Internet access and to distribute to relevant conference and meetings. The online version of the database, located at http://database.healthandenvironment.org, offers the user the opportunity to search the database by toxicant, disease, disease category or Chemical Abstract Service (CAS) number. To request additional hard copies of the spreadsheet or an electronic Excel file via email, contact Eleni Sotos, National Coordinator of the Collaborative on Health and the Environment at [email protected] About the CHE Toxicant and Disease Database (Spreadsheet Version) Human disease results from complex interactions among genes and the environment. Environmental exposures to chemical, physical, and biological agents may cause or contribute to disease in susceptible individuals. Personal lifestyle factors, such as diet, smoking, alcohol use, level of exercise, and UV exposure, often are a primary focus when considering preventable causes of disease. However, exposures to chemical contaminants on the job, at home, in the outdoors, and even in utero, are increasingly recognized as important and preventable contributors to human disease. These exposures are the focus of this project. More than 80,000 chemicals have been developed, distributed, and discarded into the environment over the past 50 years. The majority of them have not been tested for potential toxic effects in humans or animals. Some of these chemicals are commonly found in air, water, food, homes, work places, and communities. Whereas the toxicity of one chemical may be incompletely understood, an understanding of the effect from exposures to mixtures of chemicals is even less complete. Chemicals may have opposing, additive, or even synergistic effects. One example of a synergistic effect is tobacco smoking coupled with asbestos exposure, which increases the risk of lung cancer by 25-fold—a risk much higher than that resulting from the sum of the risks of the individual agents. Toxic effects of chemical agents are often not well understood or appreciated by health care providers and the general public. Some chemicals, such as asbestos, vinyl chloride and lead, are well established as causes of human disease. There also is good evidence to suggest increases in the incidence of some cancers,
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CHE_Toxicants_and_Disease_Database.160121218 - CHEMICAL...

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