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10_Lieb_non_Mendelian

10_Lieb_non_Mendelian - NonMendelian Genetics J.Lieb...

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Non-Mendelian  Genetics J. Lieb
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Announcements First midterm Friday Feb 4 – covers through Jan 31 st Bring a writing utensil – non-erasable pen Bring a SIMPLE calculator DO NOT bring a cell phone or PDA
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CONJUGATION  is the transfer of DNA through the  pilus between bacterial cells. TRANSFORMATION  is the scavenging of DNA by  bacteria . TRANSDUCTION  is the transfer of DNA into  bacteria via phage. HFR  strains have integrated an F-plasmid into  their chromosome. Review
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Mendelian Inheritance X selfe d selfe d 100% 100% 3:1 3:1 aa AA Aa Aa Aa aa AA
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X Mendelian Inheritance selfe d selfe d 100% 100% 100% 100% Hmmm...
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Non-Mendelian Inheritance 1. Cytoplasmic Inheritance 2. Maternal Effects 3. Genomic Imprinting
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(1) Genes Outside the Nucleus Mitochondria Nucleus Chloroplast (plants)
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Organelles  Circular genomes  Genomes not packaged with histones  Have prokaryotic-like gene structure  Sensitive to anti-bacterial drugs  Present in 10’s to 100’s of copies per cell  Each organelle can have multiple genomic copies  Some human diseases are linked to organelle  genes
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Endosymbiont Theory
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