10_Lieb_non_Mendelian

10_Lieb_non_Mendelian - Non-Mendelian Genetics J. Lieb...

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Unformatted text preview: Non-Mendelian Genetics J. Lieb Announcements First midterm Friday Feb 4 covers through Jan 31 st Bring a writing utensil non-erasable pen Bring a SIMPLE calculator DO NOT bring a cell phone or PDA CONJUGATION is the transfer of DNA through the pilus between bacterial cells. TRANSFORMATION is the scavenging of DNA by bacteria . TRANSDUCTION is the transfer of DNA into bacteria via phage. HFR strains have integrated an F-plasmid into their chromosome. Review Mendelian Inheritance selfe d selfe d 100% 100% 3:1 3:1 aa AA Aa Aa Aa aa AA Mendelian Inheritance selfe d selfe d 100% 100% 100% 100% Hmmm... Non-Mendelian Inheritance 1. Cytoplasmic Inheritance 2. Maternal Effects 3. Genomic Imprinting (1) Genes Outside the Nucleus Mitochondria Nucleus Chloroplast (plants) Organelles Circular genomes Genomes not packaged with histones Have prokaryotic-like gene structure Sensitive to anti-bacterial drugs Present in 10s to 100s of copies per cell Each organelle can have multiple genomic copies Some human diseases are linked to organelle genes Endosymbiont Theory...
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10_Lieb_non_Mendelian - Non-Mendelian Genetics J. Lieb...

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