Lecture_1_Introduction_2011

Lecture_1_Introduction_2011 - Welcome to BIOL202 Section 6...

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Unformatted text preview: Welcome to BIOL202 Section 6 Molecular Biology & Genetics Information on Blackboard - https://blackboard.un Advising for Biology Majors Please go to the Biology Department website http://www.bio.unc.edu/Undergraduate/ • • • • • • Degree Programs to find information about: Biology General Education Requirements Bachelor of Arts in Biology Bachelor of Science in Biology Minor in Biology • • • Advising-How to find a Biology adviser Undergraduate Advising Abbey Fellow-Dr. Elaine Yeh [email protected] • • • • • • • • • Resources Biology Majors' Manual Study Abroad Registrar's Online Services • Research Opportunities Undergraduate Research Biology Honors Program Funding & Outreach Office of Undergraduate Research Adding, Dropping, Waiting etc. • We cannot enroll beyond the room capacity. • There is no more official “wait list”. • Typically several people drop in first few weeks. • If you decide to drop please do so quickly so that others may add. • If you are waiting to add it is advisable to attend lectures and recitations. Instructors Dr. Kevin Slep 402 Fordham Hall 962-4858 [email protected] office hours by appointment Dr. Jason Lieb Teaching Assistants Deirdre Tatomer Recitations: M 1:00-1:50 (Biol601) M 2:00-2:50 (Biol602) T 3:00-3:50 (Biol603) T 4:00-4:50 (Biol604) [email protected] office hours: TBA Mira Pronobis Recitations: W 1:00-1:50 (Biol605) W 2:00-2:50 (Biol606) W 4:00-4:50 (Biol607) R 5:00-5:50 (Bio608) [email protected] office hours: TBA Introduction to Genetic Analysis 9th Edition by Griffiths et al. Text CD-ROM Solutions Manual (not required) Web Site: http://bcs.whfreeman.com/iga9e/ TESTS • 3 midterms (100 pts) Feb 4, Feb 28, April 6 • 1 Final (200 pts) Friday May 6 (8:00 AM) – cumulative • Bring non-erasable pen and a SIMPLE calculator • NO make-up exams • Re-grades in writing (within 5 class days) • NO letter grades until end of course • NO PDAs, cell phones or calculators with text memory Grading Midterms I Midterm II Midterm III Final Exam Recitation TOTAL 100 pts 100 pts 100 pts 200 pts (25+25+25+125) 55 pts 555 pts Excused exams = 4 x (final exam section) Recitations • M 1-1:50 & 2-2:50; T 3-3:50 & 44:50; W 1-1:50 , 2-2:50 & 4-4:50; R 55:50 • Wilson Hall Rm 213 • You MUST register for one • You MUST go to that one! • Switching is at discretion of TAs • ~10% of grade (problem sets, attendance & participation) Problem Sets • Roughly every other week • Some assigned from textbook • Some are “non-book” • Hand in non-book questions • Answer keys posted on web site • NO late problems accepted • Collaboration Expectations • Regular attendance in lecture & recitation • Keep up with reading • Keep up with problem sets • Your best effort in return for ours •Adherence to Honor Code (http://honor.unc.edu/honor/code.html) Transmission Genetics • What is genetics ? – What happens to information when cells divide? – How are single and multiple traits inherited? – How does gender influence inheritance? – How do genes interact? – Are there exceptions to the rules? – What is genetic mapping? – How does the cell use chromosomes? – How are genetic experiments done? – What does genetics mean for human health? WHY STUDY GENETICS? Tools for Understanding Life Medicine Lissencephaly – mutation in the Lis1 gene Down syndrome Adenomatous polyposis coli mutation Colon Polydactyly Food & Hunger Society thics Commission Gives Green Light to Synthetic Biology EW POLLACK : December 16, 2010, New York Times sident’s bioethics commission says there is no need to temporarily halt research new regulations on the controversial new field known as synthetic biology. ort being issued Thursday, the Presidential Commission for the Study of Bioethi t at present the technology — which involves creating novel organisms through is and manipulation of DNA — poses few risks because it is still in its infancy. the report recommends self-regulation by synthetic biologists. “Genetics” • From the Greek “γεννω” (genno) meaning to give birth. • Coined by the British biologist William Bateson in 1905 to describe the science of inheritance and variation. History of Genetics • Prehistory – Plant and animal breeding 12,000 years ago (GMO) • Artistic records – Assyrian sculpture showing palm breeding (883 BCE) • Sacred texts – Hindu and Jewish writing reveal an understanding of inherited characteristics Genetics in Action Genes encode phenotypes • Genes (not traits) are inherited directly • Genes, together with environmental factors determine expression of traits • An individual’s genetic information is called a GENOTYPE • The traits they express are called PHENOTYPES Molecular Information: Requirements • Structural diversity • Ability to replicate • Mutability - change • Translation – information can be read Genes Genetics Genomics Genomes The Genetic Factor • 1865 Mendel’s publication on the garden pea – “factor” responsible for traits • 1920’s-1940’s: DNA is the genetic material: Frederick Griffith Oswald Avery, Collin MacCloud, Maclyn McCarty • 1953 - Structure of DNA Rosalind Franklin, Francis Crick, James Watson Deoxyribonucleic Acid: DNA • Double Helix • Inside: Complementary Base Pairing • Outside: Backbone: Phosphate • Structural Deoxyribose diversity • Ability to replicate • Mutability • Translation DNA Replication Central Dogma DNA mRNA Protein Transcripti Translation Ribosome, tRNA - codons on RNA Polymerase Forward Genetics ) Variant phenotype ) Identify gene responsible ) Examine the role of the gene Normal vs. Variant in depth discussion with Dr. Lieb) Reverse Genetics ) Begin with known gene / mutation ) Examine phenotype nables customized analysis Tools & Methodologies • Mutagenesis • Mating Crosses • Microscopy • Probing Southern – DNA Northern – RNA Western Protein Model Organisms onsiderations for laboratory investigatio • Small size • Short generation time • Growth • Mating Model Organisms Determinants Genotype - fixed component Environment – modulates in time Developmental noise – random events Future of Genetics • Personalized genome sequencing • Personalized conventional medicine • Genetic medicines • Medicines produced in engineered plants • Synthetic organisms Next Class DNA structure & replication Reading: Chapter 7: all ...
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This note was uploaded on 02/17/2011 for the course BIOL 202 taught by Professor Kieber-hogan during the Spring '08 term at UNC.

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