Lecture_2_DNA_2011

Lecture_2_DNA_2011 - DNA Structure & Replication Jan...

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DNA Structure & Replication Jan 12 th 2011
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Review Genetics has a long history MENDEL ushered in modern genetics An individuals genetic information is called a GENOTYPE Traits individuals express are called PHENOTYPES
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Genetic material was transferred from the dead S strain to the R strain: Fredrick Griffith’s Experiment (1928) Streptococcus pneumoniae strains Smooth (S) and lethal vs. Rough (R) and semi virulent
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Avery, MacLeod & McCarty Experiment Genetic material is DNA (1944) DNase Treatment
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Hershey-Chase Experiment DNA Protein (1952) Bacteriophage T 2
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Hershey-Chase Experiment cont. Genetic material is DNA
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2' deoxyribose sugar O O O O P inorganic phosphate O C C C C O H H H H H O H H O C H H 1' 2' 3' 4' 5' What is DNA made of ?
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O thymine (T) C N O C C C N H O 1 2 3 4 5 6 H H cytosine (C) C N C C C N H H 1 2 3 4 5 6 H pyrimidines C N H C C C N H H 3 2 1 6 5 4 N N C 7 8 9 adenine (A) guanine (G) C N C C C N H H O 3 2 1 6 5 4 N N C 7 8 9 H purines What is DNA made of ? thymine (T)
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dATP (deoxyadenosine triphosphate) C N H C C C N H 3 2 1 6 5 4 N N C 7 8 9 O C C C C H H H H O H H 2' 3' 4' 5' O P O O O P O O O P O O O nucleoside linkage 3' hydroxyl 5' phosphates sugar + base + phosphate Nucleotides
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This note was uploaded on 02/17/2011 for the course BIOL 202 taught by Professor Kieber-hogan during the Spring '08 term at UNC.

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Lecture_2_DNA_2011 - DNA Structure & Replication Jan...

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